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Article

Genome Wide Methylome Alterations in Lung Cancer.

PloS one - 1 Jan 2015

Mullapudi Nandita, Ye Bin, Suzuki Masako, Fazzari Melissa, Han Weiguo, Shi Miao K, Marquardt Gaby, Lin Juan, Wang Tao, Keller Steven, Zhu Changcheng, Locker Joseph D, Spivack Simon D

Abstract excerpt

Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA 5-methyl-cytosine features which may underlie genome-wide deregulation. In one of the more dense interrogations of the methylome, we sampled 1.2 million CpG sites from twenty-four NSCLC tumor (T)-non-tumor (NT) pairs using a methylation-sensitive restriction...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Non-Small-Cell Lung
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to Oligonucleotide Array Sequence Analysis

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 26683690
DOI: 10.1371/journal.pone.0143826
PMCID: PMC4684329

Genes

HBEGF
AGER
CDH5
CST1
CTNNAL1
DACH1
DPT
FAP
FERMT1
FOXM1
GRK5
HPGD
LAMA3
MELK
NQO1
PTPN13
PTPRM
SMAD6
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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