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Article

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.

Cancer research - 15 Dec 2011

Jin Seung-Gi, Jiang Yong, Qiu Runxiang, Rauch Tibor A, Wang Yinsheng, Schackert Gabriele, Krex Dietmar, Lu Qiang, Pfeifer Gerd P

Abstract excerpt

The base 5-hydroxymethylcytosine (5hmC) was recently identified as an oxidation product of 5-methylcytosine in mammalian DNA. Here, using sensitive and quantitative methods to assess levels of 5-hydroxymethyl-2'-deoxycytidine (5hmdC) and 5-methyl-2'-deoxycytidine (5mdC) in genomic DNA, we investigated whether levels of 5hmC can distinguish normal tissue from tumor tissue. In squamous cell lung cancers, levels of...

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Identifiers

PMID: 22052461
DOI: 10.1158/0008-5472.CAN-11-2023
PMCID: PMC3242933

Genes

IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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