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5-Hydroxymethylome in Circulating Cell-Free DNA as A Potential Biomarker for Non-Small-Cell Lung Cancer

1 Jun 2018

Abstract excerpt

Non-small-cell lung cancer (NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy...

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PMID: 30010036
DOI: 10.1016/j.gpb.2018.06.002

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