Article
TLR5 Activation Exacerbates Airway Inflammation in Asthma.
Lung - 1 Apr 2020
Whitehead G S, Hussain S, Fannin R, Trempus C S, Innes C L, Schurman S H, Cook D N, Garantziotis S
Abstract excerpt
INTRODUCTION: Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysaccharide (LPS) are associated with increased asthma severity. We hypothesized that activation of the innate immune receptor TLR5 by its bacterial ligand flagellin will exacerbate airway inflammation and...
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