Article
Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.
Nature immunology - 1 Sept 2000
Karp C L, Grupe A, Schadt E, Ewart S L, Keane-Moore M, Cuomo P J, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M
Abstract excerpt
The prevalence and severity of allergic asthma continue to rise, lending urgency to the search for environmental triggers and genetic substrates. Using microarray analysis of pulmonary gene expression and single nucleotide polymorphism-based genotyping, combined with quantitative trait locus analysis, we identified the gene encoding complement factor 5 (C5) as a susceptibility locus for allergen-induced airway...
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