Article
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
eLife - 28 Jan 2020
Hussain Salik, Johnson Collin G, Sciurba Joseph, Meng Xianglin, Stober Vandy P, Liu Caini, Cyphert-Daly Jaime M, Bulek Katarzyna, Qian Wen, Solis Alma, Sakamachi Yosuke, Trempus Carol S, Aloor Jim J, Gowdy Kym M, Foster W Michael, Hollingsworth John W, Tighe Robert M, Li Xiaoxia, Fessler Michael B, Garantziotis Stavros
Abstract excerpt
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or danger-associated molecular patterns. TLR4, the prototypic receptor for LPS, also mediates inflammation after O3, triggered by endogenous hyaluronan. Regulation...
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