Article

TLR5 participates in the TLR4 receptor complex and biases towards MyD88-dependent signaling in environmental lung injury

2019-10-03

Abstract excerpt

Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, e.g. through lipopolysaccharide (LPS) or ozone (O 3 ). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or danger-associated molecular patterns. TLR4, the prototypic receptor for LPS, also mediates inflammation after O 3 , triggered by endogenous hyaluronan. Regulation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f326269-3278-5728-89b4-6325e3c48c02
DOI: 10.1101/792705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TLR5 participates in the TLR4 receptor complex and biases towards MyD88-dependent signaling in environmental lung injuryDOI 10.1101/792705Read

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.Semantic proximity Read

TLR5 Activation Exacerbates Airway Inflammation in Asthma.Semantic proximity Read

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosisSemantic proximity Read

Toll-like receptor 5 as a novel receptor for fungal zymosanSemantic proximity Read

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.Semantic proximity Read

TLR4 knock out alleviate both lung and liver inflammation caused by short-time exposure to PM2.5Semantic proximity Read

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9Semantic proximity Read

Human Toll-like receptor 4 recognizes host-specific LPS modificationsSemantic proximity Read

The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cellsSemantic proximity Read

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.Semantic proximity Read

Tlr4: central component of the sole mammalian LPS sensor.Semantic proximity Read

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.Semantic proximity Read