Article

Dysregulation of MUC5B and MUC5AC alters granulocyte frequency and activation in the lung and distal sites

2026-02-25

Abstract excerpt

<h4>Background: </h4> Mucus obstructs the airways in respiratory diseases where MUC5B is the major gel-forming mucin in COPD and MUC5AC-rich mucus dominates in asthma. Mucin production changes in response to inflammatory signals, but whether mucin dysregulation drives inflammation is less studied. Thus, we sought to identify if MUC5B and MUC5AC affect immune cell composition during homeostasis and inflammation. <...

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Literature Corpus work: f01933e4-1483-5dbe-bf2c-d45c1c20c5d5
DOI: 10.22541/au.177201557.71803671/v1

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