Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene.

Human mutation - 1 Mar 2006

Merx Sabine, Zimmer Wilma, Neumaier Michael, Ahmad-Nejad Parviz

Abstract excerpt

Toll-like receptors recognize pathogen-associated molecular patterns (PAMPs) and TLR5 is the pathogen recognition receptor (PRR) for bacterial flagellin. Patients carrying a R392 stop polymorphism display an inflammatory phenotype and increased susceptibility to pneumonia caused by the flagellated bacteria Legionella pneumophila. While this suggests that TLR5 mutations may be clinically relevant, functional data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetinae
Share to Flagellin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation, Missense

Share to Polymorphism, Genetic

Share to Toll-Like Receptor 5

Share to Transfection

Source

Identifiers

PMID: 16470719
DOI: 10.1002/humu.9409

Genes

TLR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene.PMID 16470719Read ↗

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.Semantic proximity Read ↗

A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.Semantic proximity Read ↗

Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer.Semantic proximity Read ↗

Polymorphism report: identification of two common single nucleotide polymorphisms in the human toll-like receptor 5 (TLR5) gene.Semantic proximity Read ↗

The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.Semantic proximity Read ↗

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene.Semantic proximity Read ↗

Functional TLR5 genetic variants affect human colorectal cancer survival.Semantic proximity Read ↗

A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.Semantic proximity Read ↗

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases.Semantic proximity Read ↗

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.Semantic proximity Read ↗

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease.Semantic proximity Read ↗

Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.