Article

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

2024-04-30

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a devastating pulmonary disease with no curative treatment other than lung transplantation. IPF results from maladaptive responses to lung epithelial injury, but the underlying mechanisms remain unclear. Here, we show that deficiency in the innate immune receptor, toll-like receptor 5 (TLR5), is associated with IPF in humans and with increased susceptibility to epithelial inj...

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Identifiers and source

Literature Corpus work: f86cd5ce-7e3a-5b5e-aa9f-4c2e722af1e8
DOI: 10.1101/2024.04.30.591719

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