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Article

Coevolutionary Landscape of Kinase Family Proteins: Sequence Probabilities and Functional Motifs.

Biophysical journal - 9 Jan 2018

Haldane Allan, Flynn William F, He Peng, Levy Ronald M

Abstract excerpt

The protein kinase catalytic domain is one of the most abundant domains across all branches of life. Although kinases share a common core function of phosphoryl-transfer, they also have wide functional diversity and play varied roles in cell signaling networks, and for this reason are implicated in a number of human diseases. This functional diversity is primarily achieved through sequence variation, and...

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Identifiers

PMID: 29320688
DOI: 10.1016/j.bpj.2017.10.028
PMCID: PMC5773752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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