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Article

An Asymmetrically Balanced Organization of Kinases versus Phosphatases across Eukaryotes Determines Their Distinct Impacts.

PLoS computational biology - 1 Jan 2017

Smoly Ilan, Shemesh Netta, Ziv-Ukelson Michal, Ben-Zvi Anat, Yeger-Lotem Esti

Abstract excerpt

Protein phosphorylation underlies cellular response pathways across eukaryotes and is governed by the opposing actions of phosphorylating kinases and de-phosphorylating phosphatases. While kinases and phosphatases have been extensively studied, their organization and the mechanisms by which they balance each other are not well understood. To address these questions we performed quantitative analyses of...

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PMID: 28135269
DOI: 10.1371/journal.pcbi.1005221
PMCID: PMC5279721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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