Article
Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences.
RNA biology - 1 May 2020
Hausmann Stéphane, Geiser Johan, Vadas Oscar, Ducret Verena, Perron Karl, Valentini Martina
Abstract excerpt
RNA helicases are fundamental players in RNA metabolism: they remodel RNA secondary structures and arrange ribonucleoprotein complexes. While DExH-box RNA helicases function in ribosome biogenesis and splicing in eukaryotes, information is scarce about bacterial homologs. HrpB is the only bacterial DExH-box protein whose structure is solved. Besides the catalytic core, HrpB possesses three accessory domains,...
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