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Article

Grabbing the message: structural basis of mRNA 3'UTR recognition by Hrp1.

The EMBO journal - 12 Jul 2006

Pérez-Cañadillas José Manuel

Abstract excerpt

The recognition of specific signals encoded within the 3'-untranslated region of the newly transcribed mRNA triggers the assembly of a multiprotein machine that modifies its 3'-end. Hrp1 recognises one of such signals, the so-called polyadenylation enhancement element (PEE), promoting the recruitment of other polyadenylation factors in yeast. The molecular bases of this interaction are revealed here by the...

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Identifiers

PMID: 16794580
DOI: 10.1038/sj.emboj.7601190
PMCID: PMC1500993

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