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Article

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera.

Nucleic acids research - 1 Jul 2013

Steimer Lenz, Wurm Jan Philip, Linden Martin H, Rudolph Markus G, Wöhnert Jens, Klostermeier Dagmar

Abstract excerpt

DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate. The Thermus thermophilus DEAD-box helicase Hera (for "heat-resistant RNA-binding ATPase") contains a C-terminal RNA-binding domain (RBD). We have analyzed RNA binding to the...

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Identifiers

PMID: 23625962
DOI: 10.1093/nar/gkt323
PMCID: PMC3695512

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