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Article

Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity.

PloS one - 1 Jan 2013

Fourmann Jean-Baptiste, Tillault Anne-Sophie, Blaud Magali, Leclerc Fabrice, Branlant Christiane, Charpentier Bruno

Abstract excerpt

Multiple RNA-guided pseudouridine synthases, H/ACA ribonucleoprotein particles (RNPs) which contain a guide RNA and four proteins, catalyze site-specific post-transcriptional isomerization of uridines into pseudouridines in substrate RNAs. In archaeal particles, the guide small RNA (sRNA) is anchored by the pseudouridine synthase aCBF5 and the ribosomal protein L7Ae. Protein aNOP10 interacts with both aCBF5 and...

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Identifiers

PMID: 23922977
DOI: 10.1371/journal.pone.0070313
PMCID: PMC3726423

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