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Article

Nucleotide and partner-protein control of bacterial replicative helicase structure and function.

Molecular cell - 26 Dec 2013

Strycharska Melania S, Arias-Palomo Ernesto, Lyubimov Artem Y, Erzberger Jan P, O'Shea Valerie L, Bustamante Carlos J, Berger James M

Abstract excerpt

Cellular replication forks are powered by ring-shaped, hexameric helicases that encircle and unwind DNA. To better understand the molecular mechanisms and control of these enzymes, we used multiple methods to investigate the bacterial replicative helicase, DnaB. A 3.3 Å crystal structure of Aquifex aeolicus DnaB, complexed with nucleotide, reveals a newly discovered conformational state for this motor protein....

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Share to Adenosine Triphosphate
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Electron

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Identifiers

PMID: 24373746
DOI: 10.1016/j.molcel.2013.11.016
PMCID: PMC3929961

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