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The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2015

Andrews Emma S V, Arcus Vickery L

Abstract excerpt

PhoH2 proteins are found in a diverse range of organisms that span the bacterial tree and little is known about this large protein family. PhoH2 proteins have two domains: An N-terminal PIN domain fused to a C-terminal PhoH domain. The genome of Mycobacterium tuberculosis encodes 48 PIN domains and 47 of these constitute the VapC components of the 47 VapBC toxin-antitoxins. The 48th member of the M. tuberculosis...

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Identifiers

PMID: 25999286
DOI: 10.1016/j.tube.2015.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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