Article
Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases.
Nucleic acids research - 1 Jan 2007
Zaros Cécile, Briand Jean-François, Boulard Yves, Labarre-Mariotte Sylvie, Garcia-Lopez M Carmen, Thuriaux Pierre, Navarro Francisco
Abstract excerpt
Rpb5, a subunit shared by the three yeast RNA polymerases, combines a eukaryotic N-terminal module with a globular C-end conserved in all non-bacterial enzymes. Conditional and lethal mutants of the moderately conserved eukaryotic module showed that its large N-terminal helix and a short motif at the end of the module are critical in vivo. Lethal or conditional mutants of the C-terminal globe altered the binding...
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