Article
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.
Cancer immunology research - 1 Apr 2020
Zhao Qingchuan, Laverdure Jean-Philippe, Lanoix Joël, Durette Chantal, Côté Caroline, Bonneil Éric, Laumont Céline M, Gendron Patrick, Vincent Krystel, Courcelles Mathieu, Lemieux Sébastien, Millar Douglas G, Ohashi Pamela S, Thibault Pierre, Perreault Claude
Abstract excerpt
High-grade serous ovarian cancer (HGSC), the principal cause of death from gynecologic malignancies in the world, has not significantly benefited from advances in cancer immunotherapy. Although HGSC infiltration by lymphocytes correlates with superior survival, the nature of antigens that can elicit anti-HGSC immune responses is unknown. The goal of this study was to establish the global landscape of HGSC...
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