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Article

Impact of tumor heterogeneity and microenvironment in identifying neoantigens in a patient with ovarian cancer.

Cancer immunology, immunotherapy : CII - 1 May 2021

Dao Tao, Klatt Martin G, Korontsvit Tatyana, Mun Sung Soo, Guzman Sean, Mattar Marissa, Zivanovic Oliver, Kyi Chrisann K, Socci Nicholas D, O'Cearbhaill Roisin E, Scheinberg David A

Abstract excerpt

Identification of neoepitopes as tumor-specific targets remains challenging, especially for cancers with low mutational burden, such as ovarian cancer. To identify mutated human leukocyte antigen (HLA) ligands as potential targets for immunotherapy in ovarian cancer, we combined mass spectrometry analysis of the major histocompatibility complex (MHC) class I peptidomes of ovarian cancer cells with parallel...

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Topics

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Share to Antigens, Neoplasm
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to HLA-A2 Antigen

Share to Immunotherapy, Adoptive

Share to Neoplasm Staging

Share to Ovarian Neoplasms

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 33123756
DOI: 10.1007/s00262-020-02764-9
PMCID: PMC8053669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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