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Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response.

International journal of molecular sciences - 10 Mar 2021

Hlaváč Viktor, Václavíková Radka, Brynychová Veronika, Ostašov Pavel, Koževnikovová Renata, Kopečková Katerina, Vrána David, Gatěk Jiří, Souček Pavel

Abstract excerpt

Breast cancer is the most frequent cancer in the female population worldwide. The role of germline genetic variability in cytochromes P450 (CYP) in breast cancer prognosis and individualized therapy awaits detailed elucidation. In the present study, we used the next-generation sequencing to assess associations of germline variants in the coding and regulatory sequences of all human CYP genes with response of the...

Topics

Breast Neoplasms
Cytochrome P-450 Enzyme System
Disease-Free Survival
Female
Genetic Variation
Humans
Middle Aged
Neoadjuvant Therapy
Neoplasm Proteins
Survival Rate

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PMID: 33802237
DOI: 10.3390/ijms22062826
PMCID: PMC8001203

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