Article
Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2).
Drug metabolism reviews - 1 Jan 2008
Gradhand Ulrike, Kim Richard B
Abstract excerpt
Elucidation of the key mechanisms that confer interindividual differences in drug response remains an important focus of drug disposition and clinical pharmacology research. We now know both environmental and host genetic factors contribute to the apparent variability in drug efficacy or in some cases, toxicity. In addition to the widely studied and recognized genes involved in the metabolism of drugs in clinical...
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