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Article

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance.

Pharmacogenetics and genomics - 1 Jun 2006

Leschziner Guy, Zabaneh Delilah, Pirmohamed M, Owen Andrew, Rogers Jane, Coffey Alison J, Balding David J, Bentley David B, Johnson Michael R

Abstract excerpt

BACKGROUND: The ATP-binding cassette (ABC) proteins are a superfamily of efflux pumps implicated as a mechanism for multidrug resistance in cytotoxic chemotherapy, immunosuppressive therapy, HIV and epilepsy. Genetic variation in P-glycoprotein, the product of the ABCB1 gene, is proposed to mediate de novo drug resistance, but associations between polymorphisms in ABCB1 and pharmacoresistance have produced...

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Source

Identifiers

PMID: 16708052
DOI: 10.1097/01.fpc.0000197467.21964.67

Genes

ABCB1
ABCB4
ABCC1
ABCC2
ABCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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