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Article

Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.

The American journal of pathology - 1 Nov 2004

Bellucci Arianna, Westwood Andrew J, Ingram Esther, Casamenti Fiorella, Goedert Michel, Spillantini Maria Grazia

Abstract excerpt

Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant filaments made of hyperphosphorylated tau protein and neurodegeneration leading to nerve cell loss. At 5 months of age, the pathological changes are most marked in brainstem and spinal cord. Here we show that these changes are accompanied by marked neuroinflammation. Many...

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Identifiers

PMID: 15509534
DOI: 10.1016/S0002-9440(10)63421-9
PMCID: PMC1618683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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