Article
Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker.
Gut - 1 Oct 2020
Baselli Guido Alessandro, Dongiovanni Paola, Rametta Raffaela, Meroni Marica, Pelusi Serena, Maggioni Marco, Badiali Sara, Pingitore Piero, Maurotti Samantha, Montalcini Tiziana, Taliento Alice Emma, Prati Daniele, Rossi Giorgio, Fracanzani Anna Ludovica, Mancina Rosellina Margherita, Romeo Stefano, Valenti Luca
Abstract excerpt
OBJECTIVE: Efforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the incomplete understanding of the pathogenic mechanisms and the absence of accurate non-invasive biomarkers. The aim of this study was to identify novel NAFLD therapeutic targets andbiomarkers by conducting liver transcriptomic analysis in patients stratified by the presence of the PNPLA3 I148M genetic risk variant. DESIGN: We...
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