Article
Elevated hepatic lipid and interferon stimulated gene expression in HCV GT3 patients relative to non-alcoholic steatohepatitis.
Hepatology international - 1 Nov 2016
Shrivastava Shikha, Meissner Eric G, Funk Emily, Poonia Seerat, Shokeen Virender, Thakur Arun, Poonia Bhawna, Sarin Shiv Kumar, Trehanpati Nirupma, Kottilil Shyamasundaran
Abstract excerpt
BACKGROUND AND AIMS: HCV GT-3 has a more pronounced effect on hepatic steatosis and host lipids than other HCV genotypes and is proving less responsive to all oral interferon-free treatment with direct acting antiviral agents. As both HCV GT3 infection and NASH can result in steatosis and cirrhosis, we asked whether hepatic transcriptional profiles reflective of the host response to inflammation differed based on...
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