Article

IL-32 is a stress-responsive node locked in a noncanonical NF-κB inflammatory loop during MASLD to HCC transition

2026-07-22

Abstract excerpt

<h4>Background</h4> Interleukin-32 (IL-32) presents a long-standing paradox in liver disease, with markedly elevated expression in hepatocellular carcinoma (HCC) yet a protective role against hepatic steatosis. The absence of a canonical receptor or defined secretory pathway has obscured its biological function. This study aimed to resolve this paradox by delineating the regulatory mechanisms that govern IL-32 ac...

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Literature Corpus work: 2fcbdf56-06b9-5603-824b-8793171b2dda
DOI: 10.64898/2026.07.21.739717

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