Article
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.
Nature communications - 15 Sept 2016
Thabet Khaled, Asimakopoulos Anastasia, Shojaei Maryam, Romero-Gomez Manuel, Mangia Alessandra, Irving William L, Berg Thomas, Dore Gregory J, Grønbæk Henning, Sheridan David, Abate Maria Lorena, Bugianesi Elisabetta, Weltman Martin, Mollison Lindsay, Cheng Wendy, Riordan Stephen, Fischer Janett, Spengler Ulrich, Nattermann Jacob, Wahid Ahmed, Rojas Angela, White Rose, Douglas Mark W, McLeod Duncan, Powell Elizabeth, Liddle Christopher, van der Poorten David, George Jacob, Eslam Mohammed
Abstract excerpt
Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated...
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