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IL-32 is a metabolic regulator promoting survival and proliferation of malignant plasma cells

2021-02-22

Abstract excerpt

IL-32 is a non-classical cytokine expressed in cancers, inflammatory diseases and infections. IL-32 can have both extracellular and intracellular functions, and its receptor is not identified. We here demonstrate that endogenously expressed, intracellular IL-32 binds to components of the mitochondrial respiratory chain and promotes oxidative phosphorylation. Knocking out IL-32 in malignant plasma cells significant...

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Literature Corpus work
e13c1805-04dd-5207-9b98-8ad586e9b2e5
DOI
10.1101/2021.02.22.431638
Open publication

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IL-32 is a metabolic regulator promoting survival and proliferation of malignant plasma cellsDOI 10.1101/2021.02.22.431638
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