Article
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Journal of gastroenterology and hepatology - 1 Oct 2021
Ma Hong-Lei, Chen Sui-Dan, Zheng Kenneth I, Yu Yue, Wang Xin-Xin, Tang Liang-Jie, Li Gang, Rios Rafael S, Huang Ou-Yang, Zheng Xiao-Yong, Xu Ren-Ai, Targher Giovanni, Byrne Christopher D, Wang Xiao-Dong, Chen Yong-Ping, Zheng Ming-Hua
Abstract excerpt
BACKGROUND AND AIM: Cytochrome P450 2E1 (CYP2E1) plays a role in lipid metabolism, and by increasing hepatic oxidative stress and inflammation, the upregulation of CYP2E1 is involved in development of nonalcoholic steatohepatitis (NASH). We aimed to explore the relationship between CYP2E1-333A>T (rs2070673) and the histological severity of nonalcoholic fatty liver disease (NAFLD). METHODS: We studied 438 patients...
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