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Article

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2020

Zhang Xian, Li Jie, Luo Songyuan, Wang Minjie, Huang Qin, Deng Zhiyong, de Febbo Caroline, Daoui Aida, Liew Pei Xiong, Sukhova Galina K, Metso Jari, Jauhiainen Matti, Shi Guo-Ping, Guo Junli

Abstract excerpt

OBJECTIVE: By binding to its high-affinity receptor FcεR1, IgE activates mast cells, macrophages, and other inflammatory and vascular cells. Recent studies support an essential role of IgE in cardiometabolic diseases. Plasma IgE level is an independent predictor of human coronary heart disease. Yet, a direct role of IgE and its mechanisms in cardiometabolic diseases remain incompletely understood. Approach and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Macrophages, Peritoneal

Share to Mice, Knockout, ApoE

Share to Plaque, Atherosclerotic

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Source

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Identifiers

PMID: 31996021
DOI: 10.1161/ATVBAHA.119.313744
PMCID: PMC7047522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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