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Article

Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response.

Nature communications - 1 Feb 2023

Dekkers Koen F, Slieker Roderick C, Ioan-Facsinay Andreea, van Iterson Maarten, Ikram M Arfan, van Greevenbroek Marleen M J, Veldink Jan H, Franke Lude, Boomsma Dorret I, Slagboom P Eline, Jukema J Wouter, Heijmans Bastiaan T

Abstract excerpt

Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the molecular changes involved, we here perform a transcriptome-wide association analysis of blood triglycerides, HDL cholesterol, and LDL cholesterol in 3229 individuals, followed by a systematic...

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Identifiers

PMID: 36725846
DOI: 10.1038/s41467-022-35663-x
PMCID: PMC9892529

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