Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.

doi:10.1016/j.atherosclerosis.2025.120608

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Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.

Atherosclerosis - 1 Feb 2026

Li Ya, Leberzammer Julian, Blanchet Xavier, Duan Rundan, Lacy Michael, Triantafyllidou Vasiliki, Eckardt Veit, Briem Eva, Jung Anna Simone, Su Rui, Guerra Joel, Jansen Yvonne, Hristov Michael, Enard Wolfgang, Bernhagen Jürgen, Weber Christian, Atzler Dorothee, Bartelt Alexander, Döring Yvonne, Santovito Donato, Kaltner Herbert, Ludwig Anna-Kristin, von Hundelshausen Philipp

Abstract excerpt

BACKGROUND AND AIMS: Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding protein, modulates immune functions in these cells and has been reported to attenuate atherosclerosis, though its mechanisms remain incompletely understood. Here, we...

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PMID: 41391258
DOI: 10.1016/j.atherosclerosis.2025.120608

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