Article
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
European heart journal - 14 Aug 2020
Shami Annelie, Atzler Dorothee, Bosmans Laura A, Winkels Holger, Meiler Svenja, Lacy Michael, van Tiel Claudia, Ta Megens Remco, Nitz Katrin, Baardman Jeroen, Kusters Pascal, Seijkens Tom, Buerger Christina, Janjic Aleksandar, Riccardi Carlo, Edsfeldt Andreas, Monaco Claudia, Daemen Mat, de Winther Menno P J, Nilsson Jan, Weber Christian, Gerdes Norbert, Gonçalves Isabel, Lutgens Esther
Abstract excerpt
AIMS: GITR-a co-stimulatory immune checkpoint protein-is known for both its activating and regulating effects on T-cells. As atherosclerosis bears features of chronic inflammation and autoimmunity, we investigated the relevance of GITR in cardiovascular disease (CVD). METHODS AND RESULTS: GITR expression was elevated in carotid endarterectomy specimens obtained from patients with cerebrovascular events (n = 100)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.