Article

Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation

2025-11-23

Abstract excerpt

<h4>Background and aims</h4> Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding protein, modulates immune functions in these cells and has been reported to attenuate atherosclerosis, though its mechanisms remain incompletely understood. Here, we in...

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Literature Corpus work: 8154d729-bcd7-5b54-a19a-8f1ed267a039
DOI: 10.1101/2025.11.21.689721

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