Article
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
Srikakulapu Prasad, Hu Desheng, Yin Changjun, Mohanta Sarajo K, Bontha Sai Vineela, Peng Li, Beer Michael, Weber Christian, McNamara Coleen A, Grassia Gianluca, Maffia Pasquale, Manz Rudolf A, Habenicht Andreas J R
Abstract excerpt
OBJECTIVE: Explore aorta B-cell immunity in aged apolipoprotein E-deficient (ApoE(-/-)) mice. APPROACH AND RESULTS: Transcript maps, fluorescence-activated cell sorting, immunofluorescence analyses, cell transfers, and Ig-ELISPOT (enzyme-linked immunospot) assays showed multilayered atherosclerosis B-cell responses in artery tertiary lymphoid organs (ATLOs). Aging-associated aorta B-cell-related transcriptomes...
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