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Cholesterol-Ester Transfer Protein Alters M1 and M2 Macrophage Polarization and Worsens Experimental Elastase-Induced Pulmonary Emphysema.

Frontiers in immunology - 1 Jan 2021

Santana Kelly Gomes, Righetti Renato Fraga, Breda Cristiane Naffah de Souza, Domínguez-Amorocho Omar Alberto, Ramalho Theresa, Dantas Francisca Elda B, Nunes Valéria Sutti, Tibério Iolanda de Fátima Lopes Calvo, Soriano Francisco Garcia, Câmara Niels O S, Quintão Eder Carlos Rocha, Cazita Patrícia M

Abstract excerpt

Cholesterol-ester transfer protein (CETP) plays a role in atherosclerosis, the inflammatory response to endotoxemia and in experimental and human sepsis. Functional alterations in lipoprotein (LP) metabolism and immune cell populations, including macrophages, occur during sepsis and may be related to comorbidities such as chronic obstructive pulmonary disease (COPD). Macrophages are significantly associated with...

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Identifiers

PMID: 34367144
DOI: 10.3389/fimmu.2021.684076
PMCID: PMC8334866

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