Article

Hi-GREx: A 3D Genome–Guided Framework for enhancing Gene Expression Prediction Using Hi-C–Selected Distal SNPs

2025-09-30

Abstract excerpt

Genome-Wide Association Study (GWAS) method has been successfully used to map thousands of loci associated with complex traits, but its ability to reveal the molecular mechanisms altered in complex diseases has been limited due to not including combinations and interactions between markers when predicting a disease. Transcriptome-Wide Association Studies (TWAS) estimate the aggregate effects of multiple genetic va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3a2ae82-964f-5098-b053-1e84e94cc171
DOI: 10.1101/2025.09.26.678794

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hi-GREx: A 3D Genome–Guided Framework for enhancing Gene Expression Prediction Using Hi-C–Selected Distal SNPsDOI 10.1101/2025.09.26.678794Read

Leveraging functional annotation to identify genes associated with complex diseasesSemantic proximity Read

Leveraging functional annotation to identify genes associated with complex diseases.Semantic proximity Read

Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation.Semantic proximity Read

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read

Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variationSemantic proximity Read

Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits.Semantic proximity Read

Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies.Semantic proximity Read

Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease.Semantic proximity Read

PrediXcan: Trait Mapping Using Human Transcriptome RegulationSemantic proximity Read

Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s DiseaseSemantic proximity Read

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.Semantic proximity Read

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read