Article
The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2022
Mao Xiao-Tong, Zou Wen-Bin, Cao Yu, Wang Yuan-Chen, Deng Shun-Jiang, Cooper David N, Férec Claude, Li Zhao-Shen, Chen Jian-Min, Liao Zhuan
Abstract excerpt
BACKGROUND & AIMS: A hybrid allele that originated from homologous recombination between CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP). Although suggested to cause digestive enzyme misfolding, definitive in vivo evidence for this postulate has been lacking. METHODS: CRISPR-Cas9 was used to generate humanized mice harboring the CEL-HYB1 allele on a C57BL/6J background....
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