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Article

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2026

Wilhelm Steven J, Curry Grace E, Matiwala Neel, Lin Jianguo, Quach Tran, Lowe Mark E, Sahin-Tóth Miklós, Xiao Xunjun K

Abstract excerpt

BACKGROUND & AIMS: Increasing evidence suggests that protein misfolding and proteotoxicity is an important mechanism of chronic pancreatitis (CP) in patients with genetic variants. Two mouse models carrying misfolding digestive enzyme variants, CPA1 N256K and PNLIP T221M, recapitulate the human CP phenotype. We hypothesized that both models develop CP through similar disease mechanisms. METHODS: We conducted a...

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Identifiers

PMID: 40992738
DOI: 10.1016/j.jcmgh.2025.101638
PMCID: PMC12681743

Genes

CP
CPA1
PNLIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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