Article
Association of HLA-DRB1∗09:01 with tIgE levels among African-ancestry individuals with asthma.
The Journal of allergy and clinical immunology - 1 Jul 2020
Vince Nicolas, Limou Sophie, Daya Michelle, Morii Wataru, Rafaels Nicholas, Geffard Estelle, Douillard Venceslas, Walencik Alexandre, Boorgula Meher Preethi, Chavan Sameer, Vergara Candelaria, Ortega Victor E, Wilson James G, Lange Leslie A, Watson Harold, Nicolae Dan L, Meyers Deborah A, Hansel Nadia N, Ford Jean G, Faruque Mezbah U, Bleecker Eugene R, Campbell Monica, Beaty Terri H, Ruczinski Ingo, Mathias Rasika A, Taub Margaret A, Ober Carole, Noguchi Emiko, Barnes Kathleen C, Torgerson Dara, Gourraud Pierre-Antoine
Abstract excerpt
BACKGROUND: Asthma is a complex chronic inflammatory disease of the airways. Association studies between HLA and asthma were first reported in the 1970s, and yet, the precise role of HLA alleles in asthma is not fully understood. Numerous genome-wide association studies were recently conducted on asthma, but were always limited to simple genetic markers (single nucleotide polymorphisms) and not complex HLA gene...
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