HLA-G Haplotypes Are Differentially Associated with Asthmatic Features

Abstract excerpt

HLA-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells and NK cells to influence immune responses. Unlike classical HLA molecules, HLA-G expression is not found on all somatic cells, but restricted to tissue sites, including human bronchial epithelial cells (HBEC). Individual variation of HLA-G expression is linked to its genetic polymorphism and has been associated with...

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