Article
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Genome medicine - 24 May 2022
Clay Selene M, Schoettler Nathan, Goldstein Andrew M, Carbonetto Peter, Dapas Matthew, Altman Matthew C, Rosasco Mario G, Gern James E, Jackson Daniel J, Im Hae Kyung, Stephens Matthew, Nicolae Dan L, Ober Carole
Abstract excerpt
BACKGROUND: Genome-wide association studies of asthma have revealed robust associations with variation across the human leukocyte antigen (HLA) complex with independent associations in the HLA class I and class II regions for both childhood-onset asthma (COA) and adult-onset asthma (AOA). However, the specific variants and genes contributing to risk are unknown. METHODS: We used Bayesian approaches to perform...
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