Article
Multiethnic genome-wide and HLA association study of total serum IgE level.
The Journal of allergy and clinical immunology - 1 Dec 2021
Daya Michelle, Cox Corey, Acevedo Nathalie, Boorgula Meher P, Campbell Monica, Chavan Sameer, Cho Michael H, David Gloria L, Kachroo Priyadarshini, Lasky-Su Jessica, Li Xingnan, McHugh Caitlin P, Qiao Dandi, Rafaels Nicholas, Beck Lisa A, Bleecker Eugene R, Caraballo Luis, Cupples Adrienne L, Figueiredo Camila A, Gallo Richard L, Hanifin Jon, Hansel Nadia N, Hata Tissa R, Hersh Craig P, Knight-Madden Jennifer, Leung Donald Y M, Guttman-Yassky Emma, Meyers Deborah A, O'Connor George, Ober Carole, Ong Peck Y, Ortega Victor E, Paller Amy S, Putcha Nirupama, Reed Robert M, Schneider Lynda C, Silverman Edwin K, Slifka Mark K, Spergel Jonathan M, Vasan Ramachandran S, Viaud-Martinez Karine A, Watson Harold, Weiss Scott T, Ruczinski Ingo, Beaty Terri H, Mathias Rasika A, Barnes Kathleen C
Abstract excerpt
BACKGROUND: Total serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE. OBJECTIVE: We aimed to increase understanding of genetic variants affecting tIgE production across the ancestry and allergic disease spectrum by leveraging data from the National Heart, Lung and Blood Institute...
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