Article
Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Aug 2013
Potaczek Daniel P, Michel Sven, Sharma Vishwas, Zeilinger Sonja, Vogelberg Christian, von Berg Andrea, Bufe Albrecht, Heinzmann Andrea, Laub Otto, Rietschel Ernst, Simma Burkhard, Frischer Thomas, Genuneit Jon, Illig Thomas, Kabesch Michael
Abstract excerpt
BACKGROUND: Recently, three genome-wide association studies (GWAS) demonstrated FCER1A, the gene encoding a ligand-binding subunit of the high-affinity IgE receptor, to be a major susceptibility locus for serum IgE levels. The top association signal differed between the two studies from the general population and the one based on an asthma case-control design. In this study, we investigated whether different...
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