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Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians

31 May 2025

Abstract excerpt

Asthma is a prevalent respiratory condition with over 100 genetic loci identified through genome-wide association studies (GWAS). However, the genetic basis of asthma in East Asians remains underexplored. To address this, we performed a comprehensive analysis of shared genetic mechanisms between asthma and white blood cell (WBC) traits in East Asians, aiming to identify potential pleiotropic loci. Using linkage...

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PMID: 40450010
DOI: 10.1038/s41467-025-60405-0

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