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Article

Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.

PloS one - 1 Jan 2020

Lee Eun-Gyung, Tulloch Jessica, Chen Sunny, Leong Lesley, Saxton Aleen D, Kraemer Brian, Darvas Martin, Keene C Dirk, Shutes-David Andrew, Todd Kaitlin, Millard Steve, Yu Chang-En

Abstract excerpt

The apolipoprotein E gene (APOE) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet the expression of APOE is not clearly understood. For example, it is unclear whether AD patients have elevated or decreased APOE expression or why the correlation levels of APOE RNA and the ApoE protein differ across studies. Likewise, APOE has a single CpG island (CGI) that overlaps with its...

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Identifiers

PMID: 31978088
DOI: 10.1371/journal.pone.0227667
PMCID: PMC6980611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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