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Article

Screening reveals conserved and nonconserved transcriptional regulatory elements including an E3/E4 allele-dependent APOE coding region enhancer.

Genomics - 1 Nov 2008

Chen Hsuan Pu, Lin Andy, Bloom Joshua S, Khan Arshad H, Park Christopher C, Smith Desmond J

Abstract excerpt

We performed an unbiased experimental search for enhancers and silencers in a 153-kb region containing the human apolipoprotein (APO) E/C1/C4/C2 gene cluster using shotgun cloning into a luciferase vector. A continuum of transcriptional effect sizes was observed, possibly explaining the limited success of bioinformatics in identifying regulatory regions. We identified nine statistically significant enhancers and...

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Share to Apolipoprotein E3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18718521
DOI: 10.1016/j.ygeno.2008.07.009

Genes

APOE

Provenance

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