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Article

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15.

Epigenetics - 1 Jan 2000

Zhang Xiao, Ehrlich Kenneth C, Yu Fangtang, Hu Xiaojun, Meng Xiang-He, Deng Hong-Wen, Shen Hui, Ehrlich Melanie

Abstract excerpt

A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants because only a very small percentage of variants associated with a given trait actually impact the trait. We used an extensive epigenetics, transcriptomics, and genetics analysis of the TBX15/WARS2 neighbourhood to prioritize this region's best-candidate causal variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31975641
DOI: 10.1080/15592294.2020.1716491
PMCID: PMC7574382

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